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July 15, 2008

Can that spam

Filed under: Uncategorized — admin @ 5:17 pm

Are you fed up with opening your email account and finding your inbox full of spam?

From today it is a criminal offence for European companies to send unsolicited e-mails. Companies and individuals who break the law could face fines of up to £5,000.

Spam now accounts for 50 per cent of all e-mails across the world; in 2001 it accounted for less than one in ten of all internet traffic.

It’s thought that 200 professional spammers around the world account for 80 per cent of the messages, selling anything from prescription medicines like Viagra to soft porn sites.

And it’s reckoned that wading through these unsolicited messages costs European Businesses more than £1bn a year.

This morning, Breakfast asked: will the new anti-spam laws work?

* Mike Sergeant met one man who conducts a battle against the spammers from a house-boat on the river Thames. Steve Linford runs the website Spamhaus.

click here to watch Mike Sergeant’s report
* We talked to the new Information Commissioner Richard Thomas, who will implement the new rules – and Nick Scales, from the internet security company Avecho.

click here to watch our debate in full with Richard Thomas and Nick Scales
* We also want to know what you think. Read on for more details – or jump to Breakfast’s email form.
click here to go straight to our E-mail form

What to do about spam
* Never reply to spam – no matter how tempting the offer.
* Do not click on anything which says “unsubscribe here”: your reply will simply confirm that yours is an active e-mail address.
* The Telephone Preference Service – which deals with unwanted phone canvassers – will also regulate Spam. Hotline: 0845 0700707
* If you have received Spam, you can report it to the office of the Information Commissioner:

Click here for the Information Commissioner’s website

Some anti-spam websites

Avecho

Click here to find out more about Mailwasher, an anti-spam technology device.

Spamhaus

web abacus

Are you plagued by spam – or is does it serve a useful purpose? Tell Breakfast what you think

Name
Your E-mail address
Where you live
Comments

Disclaimer: The BBC may edit your comments and cannot guarantee that all e-mails will be published.

July 2, 2008

Aldosterone Inhibitors in Infants and Children

Filed under: Uncategorized — admin @ 4:42 pm

Adverse Effects

The most frequent adverse effects associated with aldosterone inhibitors are electrolyte imbalances, including hyponatremia, hyperkalemia, and hyperchloremic metabolic acidosis. Other less common adverse effects include: drowsiness, headache, lethargy, ataxia, rash, diarrhea, vomiting, abdominal cramps, and gastritis. Rare adverse effects reported with spironolactone include bone marrow suppression, gastrointestinal bleeding, ototoxicity, and nephrocalcinosis. The aldosterone inhibitors have also been shown to produce tumors in rats during chronic toxicity studies, but no cases of cancer have been reported in humans.[4,26]

With prolonged use of spironolactone, up to 10% of patients experience adverse effects from inhibition of testosterone and progesterone, including gynecomastia, impotence, and irregular menses or amenorrhea. These effects are related to both dose and duration of therapy and typically reverse with discontinuation.[4] Eplerenone, with its greater selectivity for aldosterone receptors, has much less potential to cause these effects, and may become the preferred agent for long-term therapy in children.

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